_{Using flexible microparticles as drug carriers to shuttle nanoparticles to the vascular wall| Phys.org}

Provided by Thamarasee Jeewandara , Phys.org

Material properties of NP-loaded hydrogel MPs. (A) Schematic and representative confocal microscopy fluorescence images of hydrogel MPs evaluated, having varied modulus and NP loading. Red is MP hydrogel, green is 50-nm PS NPs, and the two are overlaid to show colocalization of NPs and hydrogel MPs. Scale bar, 5 μm. Swollen shear moduli for (B) 15% PEG and (C) 50% PEG hydrogels showing the influence of adding NPs to bulk material rheometry. Statistical analyses were performed using one-way analysis of variance (ANOVA) with Fisher’s least significant difference (LSD) test, where (***) indicates P < 0.001 in comparison to the nonloaded hydrogels. N = 3. Error bars plot SE. Credit: Science Advances, doi: 10.1126/sciadv.abe0143

https://phys.org/news/2021-05-flexible-microparticles-drug-carriers-shuttle.html

Sourced via: Nanotechnology news – Science X Phys.org

More information: 

Fish M. B. et al. Deformable microparticles for shuttling nanoparticles to the vascular wall, Science Advances, DOI: 10.1126/sciadv.abe0143

Nel A. E. et al. Understanding biophysicochemical interactions at the nano-bio interface. Nature Materials, doi.org/10.1038/nmat2442

Tasciotti, E. et al. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nature Nanotechnology, doi.org/10.1038/nnano.2008.34

Journal information: Nature Materials , Science Advances , Nature Nanotechnology

Science X is a network of high-quality websites that provides the most complete and comprehensive daily coverage of science, technology, and medical news.

_{Listening to Calming Music at Bedtime Promotes Better Sleep | Neuroscience News}

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Older adults who listened to calming music before sleep, or while falling asleep, had better sleep quality than those who did not.

https://neurosciencenews.com/sleep-music-18274/

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Sign up for their FREE newsletters and get the latest neuroscience headlines and summaries sent to your email once a day, totally free. delivered direct to your inbox.

_{Warning Signs of Ulcerative Colitis | Slideshow}

Reviewed by Arefa Cassoobhoy, MD, MPH on July 27, 2020

UC is a bowel disease that causes inflammation of the cells lining your large intestine. This may lead to sores that can bleed and keep your body from digesting food like it should. Here’s what to watch for.

Image by VEM/Photo Researchers

https://www.webmd.com/ibd-crohns-disease/ulcerative-colitis/ss/slideshow-uc-overview

This tool does not provide medical advice. See additional information.

_{Out Now: New Issue of EMJ Radiology}

An open-access eJournal that provides healthcare professionals with peer-reviewed articles written by experts, exclusive interviews, and highlights from the European Congress of Radiology (ECR) 2021. These are accompanied by abstract summaries of presentations from the congress.

DAILY UPDATE on COVID-19 via EMJ > European Medical Journal on paper.li

http://news.emjreviews.com

EMJ reviews all of the breaking news from the major healthcare congresses across Europe and North- America. Subscribe for updates

_{Health, Medical, Research, Patient and Pharma related newsletters}

A selection of self-updating Health, Medical, Research, Patient and Pharma related paperli newsletters for everyone #notjustpatients. Addressing issues regarding health and medical wellbeing, chronic and rare diseases, clinical research, pharma industry and drug development.

https://fibroflutters.com/2021/02/20/health-medical-research-patient-pharma-newsletters-selfupdating/

The above post includes a link to our very own The #chronicillnessVOICE Daily newsletter for everyone #notjustpatients paper.li

_{Virtual Public Genomics Café}

Friday 14 May 2021, 12 – 2pm

(this café is taking place as part of the Genomics Showcase)

The Café is free to join and will be an informal opportunity to meet others and find out about new advances in the area of genomic medicine in Wales. It will also be a chance for people to come together, and let us know how we can better support those affected by rare or genetic conditions.

The special café is being held as part of the first ever Genomics Showcase in Wales and will feature relaxed talks from speakers including:

• Covid-19 a year on: Professor Keir Lewis, Hywel Dda University Health Board
• Experiences of a Rare Disease Parent Advocate: Marie James
• The Role of Rare Copy Number Variants in psychiatric disorders: Dr Kim Kendall, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University
• Getting involved in Genomics in Wales: Patient & Public Sounding Board Members, Genomics Partnership Wales
• Opportunity for discussion and networking

As the café is part of the Genomics Showcase, you will need to register for the via the specific link below. This will give you access to the entire Showcase (including talks, stands, activities, films and more) including the café.

_{Advancing Research Through the Global PNH Patient Registry}

Date:
May 12, 2021

Time:
1:00 – 2:00pm ET

The landscape of rare drug development is constantly evolving. Gain knowledge on these important changes; interact with experts, patients, and advocates in the field and ultimately discover your role in advancing drug therapies at our 2021 RARE Drug Development Symposium happening virtually June 9-11, 2021.

New to this year’s event is an optional pre-conference workshop on June 9, targeted to attendees who are in the early stages of research engagement and looking to build knowledge in core competencies that will be expanded upon in the main event program.

Register now for this year’s event to deepen your understanding of rare disease drug development efforts!